Welcome to Half Baked, the newsletter serving up startup ideas as fast as AI companies snapped up Super Bowl ad spots this year 🏈
In today’s edition:
💡 An idea to serve millions of patients in need
🛠 Building full-stack apps with Base44 (5-Day Mini Course)
🔋 Building a $1.8B Business in 2 years + more
🔍 Anthropic raise, Mr Beast acquisition + more
🍻 An alarm clock that literally runs away from you
Let’s goooo 🚀
💸 The Baked44 Challenge: We've teamed up with Base44 to give away $5K to one founder who ships their product this February. More details here and later in the newsletter.
Happy building!
💊 Clinical Trial Matching Platform
Trial blazing
Available domain: Triall.com
The Problem: There are over 400,000 active clinical trials on ClinicalTrials.gov right now. For a cancer patient with limited options, that sounds like good news, until you realize that 80% of trials fail to meet enrollment deadlines. Not because patients don't exist, but because they can't find each other. Patients spend 40+ hours searching through trials written in dense medical jargon, only to discover they don't qualify. Meanwhile, pharma companies are spending $30,000 per enrolled patient on recruitment. The timing couldn't be better - AI can finally parse unstructured medical records, and decentralized trials mean geography matters less than ever. Here's what we're thinking.
The Solution:
💡 The Idea: A patient-facing search engine that matches patients to clinical trials for treatments for their conditions
🛠️ Product:
A patient uploads their diagnosis, lab results, and treatment history securely and gets matched to relevant trials within 24 hours.
AI translates complex eligibility criteria into plain English and tells you exactly why you do or don't qualify.
One-click pre-screening forms sent directly to trial coordinators, cutting weeks off the enrollment process.
🧑💻 Prototyping: Try the demo (built in Base44) | Get the demo prompt
💼 Business Model: Free for patients. Pharma companies and CROs pay $200-500 per qualified referral.
⭐ End Goal: Acquisition by clinical trial management companies (Medidata, Veeva) or pharma services giants (IQVIA) at 10-15x revenue.
Rate this idea
📱 Give Your Business an Edge with SuperMobile
You've built a great product. Now, make sure your connection gives your team and client services the edge it needs to grow big while staying secure.
Runs on America's Best 5G Network - your calls and video stay crisp
T-Satellite kicks in automatically when cell towers can't reach - no setup needed
Built-in Threat Protect blocks malware and phishing on any network
Starts at $42/line/mo. Learn more on T-Mobile's website.
*With 6+ lines on SuperMobile. With AutoPay; plus taxes and fees.
💻 Building Full-Stack Apps with Base44 (5-Day Mini Course)
The Context: AI app builders are everywhere right now - Bolt, Lovable, Replit, and more. This week we're running a 5-day course using Base44 to show you what's actually possible with these tools. Days 1-3 cover the fundamentals: getting started, frontend, and backend. Days 4-5 we build two real apps - a SaaS product and a marketplace. Today, we're starting simple with a task list.
Step-by-step:
Go to base44.com, create a free account, and click "Start Building" to open your first project.
In the prompt box, type: "Build a simple task list app where I can add tasks, mark them complete, and delete them" - then watch Base44 generate your app.
Try it out, then iterate by typing things like "add a priority field with high, medium, low options" or "let me filter by completion status" to see how the conversation-based editing works.
Click Publish to get a live link you can share - you've just built and deployed your first app.
Get the full guide (and don’t forget to claim your free credits here)
P.S. In tomorrow's newsletter, you'll learn how to build polished landing pages with Base44.
🤖 Save 10+ Hours Per Week Using AI as Your Personal Assistant
Drowning in tasks while dreaming of a way to clone yourself? Your AI productivity breakthrough has arrived.
Get the exact templates used by top performers to delegate 80% of their routine work to AI
Access the "AI Assistant Command Center" - a ready-to-use system for managing all your AI tools
Master AI delegation in under 60 minutes with a step-by-step implementation guide
Leverage advanced prompts that turn ChatGPT into your 24/7 productivity partner
Over 10,000 professionals have already transformed their productivity using these templates.
🔋 Founder Fuel
🤑 Money Shot: These guys built a $1.8B business in just 2 years. Here's how.
📈 Trends with Benefits: We’re starting to see ads appear in ChatGPT (and will in other LLMs). Here’s why.
💬 Prompt Drop: This vibe coding prompt to help build any app went super viral recently.
🆓 Founder Resource: This complete guide to building Claude skills from Anthropic is worth a look!
💵 Founder Deal: Get a 45-day free trial of Wispr Flow on us, our most used AI tool at Half Baked.
🔍 Founder Finds
💰 Anthropic is closing in on a $20B funding round. I would kill to be an investor…
💳 Mr Beast’s company Beast Industries just acquired Step, a banking app geared towards teens.
🚀 Patrick Collison shared his framework for moving fast, the most important thing in a startup.
📰 Rian Sweet just wrote about clearing your “allostatic load,” which makes laziness impossible. Some really great learnings in here.
📚 This guy just shared a great roadmap to master AI in 30 days. Well worth a look!
🍺 Drunk Business Idea: Runaway Alarm
Still struggling to get out of bed in the mornings? Need an extra push to get you going?
Introducing Clocky™, the alarm clock on wheels that jumps off your nightstand and rolls around your room beeping until you physically chase it down. Features an R2D2-like robotic screech and can survive a 3-foot drop. Because nothing says "good morning" like cardio.
Clocky™ - You’ve run out of excuses.
Vote
👋 That’s All Folks!
Before you go just a few public service announcements:
Looking to sponsor Half Baked? Just fill out this form and we’ll get back to you asap.
See you soon,